top of page

Research Publications

Professor Semsarian is a physician scientist whose research focus over the last 25 years has been in the field of genetic cardiovascular disease. He is both a cardiologist and a researcher. His work focuses on identifying new genes in cardiovascular disease, elucidating the molecular basis of how these genes lead to the clinical phenotype, and evaluating the role of modifying factors in clinical disease development and progression. Professor Semsarian completed a successful PhD at the Victor Chang Cardiac Research Institute (1999), and subsequently studied at the Department of Genetics, Harvard Medical School, Boston (1999-2001).


Professor Semsarian returned to Australia in 2001 and established the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute, University of Sydney. Professor Semsarian has over 400 peer-reviewed scientific publications in leading cardiology and scientific journals including Nature, New England Journal of Medicine, Journal of Clinical Investigation, Lancet, JAMA, Circulation, British Medical Journal, Genetics in Medicine, and Journal of the American College of Cardiology.

Selected Publications


TeamCardio Retreat 2022

  1. Bagnall RD, Weintraub RG, Ingles J, Duflou J, Yeates L, Lam L, Davis AM, Thompson T, Connell V, Wallace J, Naylor C, Crawford J, Love DR, Hallam L, White J, Lawrence C, Lynch M, Morgan N, James P, du Sart D, Puranik R, Langlois N, Vohra J, Winship I, Atherton J, McGaughran J, Skinner JR, Semsarian C. A Prospective Study of Sudden Cardiac Death among Children and Young Adults. N Engl J Med 2016;374:2441-2452.

  2. Semsarian C, Ingles J, Wilde AA. Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives. Eur Heart J 2015;36:1290-1296.

  3. Ingles J, Spinks C, Yeates L, McGeechan K, Kasparian N, Semsarian C. Posttraumatic Stress and Prolonged Grief After the Sudden Cardiac Death of a Young Relative. JAMA Intern Med 2016;176:402-405.

  4. Semsarian C, Ingles J, Maron MS, Maron BJ. New perspectives on the prevalence of hypertrophic cardiomyopathy. J Am Coll Cardiol 2015;65:1249-1254.

  5. Maron BJ, Spirito P, Shen WK, Haas TS, Formisano F, Link MS, Epstein AE, Almquist AK, Daubert JP, Lawrenz T, Boriani G, Estes NA, 3rd, Favale S, Piccininno M, Winters SL, Santini M, Betocchi S, Arribas F, Sherrid MV, Buja G, Semsarian C, Bruzzi P. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA 2007;298:405-412.

  6. Ingles J, Burns C, Barratt A, Semsarian C. Application of Genetic Testing in Hypertrophic Cardiomyopathy for Preclinical Disease Detection. Circ Cardiovasc Genet 2015;8:852-859.

  7. Ingles J, Semsarian C. The value of cardiac genetic testing. Trends Cardiovasc Med 2014;24:217-224.

  8. Semsarian C, Wu MJ, Ju YK, Marciniec T, Yeoh T, Allen DG, Harvey RP, Graham RM. Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway. Nature 1999;400:576-581.

  9. Maron BJ, Maron MS, Semsarian C. Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives. J Am Coll Cardiol 2012;60:705-715.

  10. Ingles J, Semsarian C. The Australian Genetic Heart Disease Registry. Int J Cardiol 2013;168:e127-128.

For a complete list of publications by Professor Semsarian, click here

bottom of page